Factor II and Factor V Leiden
Factor II and Factor V are important components of the coagulation cascade. Testing for Factor ll and Factor V Leiden mutations provides important information in a differential diagnosis for the clinical presentation of thrombophilia. Factor V is the most common variant associated with inherited thrombosis, with a population frequency ranging from 3-8% in the United States. Factor II is the second most common mutation — present in 1-2% of the general population.
Based on the dominant mode of inheritance, the testing of direct family members (parents, siblings and children) is strongly recommended.